Enzyme Inhibitors

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Organic Chemistry / Enzyme Inhibitors / Cell line / Humans / Drug Resistance / L-asparaginase / Tight Binding / Cell Proliferation / Chemistry Biology / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Fghfgh / L-asparaginase / Tight Binding / Cell Proliferation / Chemistry Biology / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Fghfgh

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Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Microbiology / Medicinal Chemistry / Molecular Biology / Biology / Malaria / Enzyme Inhibitors / Public Health / Protease / Host Parasite Interaction / Enzyme Inhibitors / Public Health / Protease / Host Parasite Interaction

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Protein Farnesyltransferase and Protein Prenylation in Plasmodium falciparum

Enzyme Inhibitors / Biological Chemistry / Biological Sciences / Animals / Biological / Enzyme / CHEMICAL SCIENCES / Diterpenes / Substrate Specificity / Plasmodium falciparum / Antimalarials / Amino Acid Profile / Protozoan Proteins / Enzyme / CHEMICAL SCIENCES / Diterpenes / Substrate Specificity / Plasmodium falciparum / Antimalarials / Amino Acid Profile / Protozoan Proteins

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Nitric Oxide Regulates Local Arterial Distensibility In Vivo

Enzyme Inhibitors / Elasticity / Hemodynamics / Sheep / Blood Pressure / Nitric oxide / Animals / Acetylcholine / Clinical Sciences / Nitric Oxide Synthase / Public health systems and services research / Circulation / Nitroglycerin / Extremities / Nitric oxide / Animals / Acetylcholine / Clinical Sciences / Nitric Oxide Synthase / Public health systems and services research / Circulation / Nitroglycerin / Extremities

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Menthol-Induced Ca2+ Release from Presynaptic Ca2+ Stores Potentiates Sensory Synaptic Transmission

Neuroscience / Calcium / Enzyme Inhibitors / Patch-clamp and imaging techniques / Glutamate / Transient receptor potential channels / Animals / Spinal Cord / Sensory Neuron / Synaptic Transmission / Rats / SYNAPSES / Chelating Agents / Boron Compounds / Patch Clamp / Dorsal Horn / Menthol / Phospholipase C / Excitatory Postsynaptic Potentials / Glutamate release / Transient receptor potential channels / Animals / Spinal Cord / Sensory Neuron / Synaptic Transmission / Rats / SYNAPSES / Chelating Agents / Boron Compounds / Patch Clamp / Dorsal Horn / Menthol / Phospholipase C / Excitatory Postsynaptic Potentials / Glutamate release

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Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A 2

Calcium / Enzyme Inhibitors / Flavonoids / Animals / Male / Epidermis / Clinical Sciences / Guinea Pig / Quercetin / Structure activity Relationship / Biochemistry and cell biology / Apigenin / Epidermis / Clinical Sciences / Guinea Pig / Quercetin / Structure activity Relationship / Biochemistry and cell biology / Apigenin

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Detection of NADPH-diaphorase activity in Paramecium primaurelia

Microbiology / Medical Microbiology / Immunohistochemistry / Enzyme Inhibitors / Animals / Acetylcholine / Rat Brain / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Enzyme / European / Active site / Nitric Oxide Synthase / Substrate Specificity / Molecular Mass / NAD / Hydrogen-Ion Concentration / Paramecium / Cell Cell Interaction / Immunoblotting / Acetylcholine / Rat Brain / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Enzyme / European / Active site / Nitric Oxide Synthase / Substrate Specificity / Molecular Mass / NAD / Hydrogen-Ion Concentration / Paramecium / Cell Cell Interaction / Immunoblotting

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Vascular endothelial growth factor increases the intracellular magnesium

Endocrinology / Neuroscience / Neurology / Electrophysiology / Animal Behavior / Stem Cells / Traumatic Brain Injury / Neurogenesis / Migration / Microcirculation / Calcium / Enzyme Inhibitors / Biological Chemistry / Flavonoids / Stem Cell / Gene expression / Extracellular Matrix / Animal Production / Cell Culture / Cell Division / Signal Transduction / Pathophysiology / Biological Sciences / Transplantation / Microvascular Physiology / In Vitro / Cell Differentiation / Neurovascular / Humans / Brain Circulation / Mice / VEGF / Animals / Male / Polymerase Chain Reaction / Statistical Significance / Astrocyte / Vascular endothelium / Perfusion / Skin / Acute Pancreatitis / Chemotaxis / Matrix metalloproteinases (MMPs) / Nickel / Fibroblast Growth Factor / Clinical Sciences / CHEMICAL SCIENCES / Middle Aged / mRna expression levels / Cerebral / Adult / Endothelial cell / Protease Inhibitors / Time Factors / Myocyte / Veterinary Sciences / Cell Proliferation / Surgical / Growth Factor / Vascular Permeability / Cell Survival / Subventricular Zone / Neurosciences / Rana temporaria / islets of Langerhans / Vascular Endothelial Growth Factor / Adenosine Triphosphate / Matrix Metalloproteinase / Vascular Resistance / Transforming Growth Factor / Brain injuries / Neuropsychological Tests / Stem Cells / Traumatic Brain Injury / Neurogenesis / Migration / Microcirculation / Calcium / Enzyme Inhibitors / Biological Chemistry / Flavonoids / Stem Cell / Gene expression / Extracellular Matrix / Animal Production / Cell Culture / Cell Division / Signal Transduction / Pathophysiology / Biological Sciences / Transplantation / Microvascular Physiology / In Vitro / Cell Differentiation / Neurovascular / Humans / Brain Circulation / Mice / VEGF / Animals / Male / Polymerase Chain Reaction / Statistical Significance / Astrocyte / Vascular endothelium / Perfusion / Skin / Acute Pancreatitis / Chemotaxis / Matrix metalloproteinases (MMPs) / Nickel / Fibroblast Growth Factor / Clinical Sciences / CHEMICAL SCIENCES / Middle Aged / mRna expression levels / Cerebral / Adult / Endothelial cell / Protease Inhibitors / Time Factors / Myocyte / Veterinary Sciences / Cell Proliferation / Surgical / Growth Factor / Vascular Permeability / Cell Survival / Subventricular Zone / Neurosciences / Rana temporaria / islets of Langerhans / Vascular Endothelial Growth Factor / Adenosine Triphosphate / Matrix Metalloproteinase / Vascular Resistance / Transforming Growth Factor / Brain injuries / Neuropsychological Tests

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DNA repair deficiency as a therapeutic target in cancer

Genetics / Enzyme Inhibitors / DNA repair / Humans / Neoplasms / Antineoplastic Agents

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Sesquiterpene lactones inhibit luciferase but not β-galactosidase activity in vitro and ex vivo

Analytical Chemistry / Enzyme Inhibitors / Gene expression / Escherichia coli / Animals / NF-kappa B / Analytical / Transcription Factor / Enzyme / Sesquiterpenes / Time Factors / Biological activity / Analytical Biochemistry / Lactones / Biochemistry and cell biology / Statistics as Topic / NF-kappa B / Analytical / Transcription Factor / Enzyme / Sesquiterpenes / Time Factors / Biological activity / Analytical Biochemistry / Lactones / Biochemistry and cell biology / Statistics as Topic

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Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors

Organic Chemistry / Enzyme Inhibitors / Bioorganic Chemistry / Cell line / Humans / Proteasome / Amino Acids / Active site / Amino Acid Profile / Bioorganic / PROTEASOME INHIBITOR / Proteasome / Amino Acids / Active site / Amino Acid Profile / Bioorganic / PROTEASOME INHIBITOR

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Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 Deficiency Reduces Leukocyte Infiltration into Adipose Tissue and Favors Fat Deposition

Obesity / Skeletal muscle biology / Diabetes / Flow Cytometry / Enzyme Inhibitors / Insulin Resistance / Adipose tissue / Humans / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Amines / Mice / Animals / Blood / Male / Plasma / Deposition / Phosphorylation / Phosphotyrosine / Cattle / Rats / Infiltration / Substrate Specificity / Deficiency / Adipocytes / Fat / Wistar Rats / Type 2 Diabetes Mellitus / Deficit / Recombinant Proteins / Alzheimer Disease / Protein Tyrosine Phosphatases / Monoamine oxidase / Leukocytes / Semicarbazide / Amine / islets of Langerhans / Cell Adhesion Molecules / The American / Insulin Resistance / Adipose tissue / Humans / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Amines / Mice / Animals / Blood / Male / Plasma / Deposition / Phosphorylation / Phosphotyrosine / Cattle / Rats / Infiltration / Substrate Specificity / Deficiency / Adipocytes / Fat / Wistar Rats / Type 2 Diabetes Mellitus / Deficit / Recombinant Proteins / Alzheimer Disease / Protein Tyrosine Phosphatases / Monoamine oxidase / Leukocytes / Semicarbazide / Amine / islets of Langerhans / Cell Adhesion Molecules / The American

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Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein1 Activity Exerts an Antidiabetic Action in Goto-Kakizaki Rats

Obesity / Skeletal muscle biology / Diabetes / Flow Cytometry / Enzyme Inhibitors / Insulin Resistance / Adipose tissue / Humans / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Amines / Mice / Animals / Blood / Male / Plasma / Deposition / Phosphorylation / Phosphotyrosine / Cattle / Rats / Infiltration / Substrate Specificity / Deficiency / Adipocytes / Fat / Wistar Rats / Type 2 Diabetes Mellitus / Deficit / Recombinant Proteins / Alzheimer Disease / Protein Tyrosine Phosphatases / Monoamine oxidase / Leukocytes / Semicarbazide / Amine / islets of Langerhans / Cell Adhesion Molecules / The American / Insulin Resistance / Adipose tissue / Humans / Glucose / Blood Glucose / Insulin / Diabetes mellitus / Amines / Mice / Animals / Blood / Male / Plasma / Deposition / Phosphorylation / Phosphotyrosine / Cattle / Rats / Infiltration / Substrate Specificity / Deficiency / Adipocytes / Fat / Wistar Rats / Type 2 Diabetes Mellitus / Deficit / Recombinant Proteins / Alzheimer Disease / Protein Tyrosine Phosphatases / Monoamine oxidase / Leukocytes / Semicarbazide / Amine / islets of Langerhans / Cell Adhesion Molecules / The American

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Na Self Inhibition of Human Epithelial Na Channel: Temperature Dependence and Effect of Extracellular Proteases

Physiology / Kinetics / Enzyme Inhibitors / Molecular Mechanics / Humans / Animals / Temperature / Trypsin / Medical Physiology / High Temperature / Steady state / Temperature Dependence / Homeostasis / Sodium / Sodium channel / Voltage-Gated Sodium Channels / Xenopus laevis / Benzimidazoles / Oocytes / Extracellular Space / General Physiology / Animals / Temperature / Trypsin / Medical Physiology / High Temperature / Steady state / Temperature Dependence / Homeostasis / Sodium / Sodium channel / Voltage-Gated Sodium Channels / Xenopus laevis / Benzimidazoles / Oocytes / Extracellular Space / General Physiology

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Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness

British / Enzyme Inhibitors / Allergy / Nitric oxide / Animals / Allergens / Behavioral Animal Models / Nitric Oxide Synthase / Trachea / Arginine / bronchial hyperreactivity (BHR) / AIRWAY HYPERRESPONSIVENESS / Allergens / Behavioral Animal Models / Nitric Oxide Synthase / Trachea / Arginine / bronchial hyperreactivity (BHR) / AIRWAY HYPERRESPONSIVENESS

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Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness

British / Enzyme Inhibitors / Allergy / Nitric oxide / Animals / Allergens / Behavioral Animal Models / Nitric Oxide Synthase / Trachea / Arginine / bronchial hyperreactivity (BHR) / AIRWAY HYPERRESPONSIVENESS / Allergens / Behavioral Animal Models / Nitric Oxide Synthase / Trachea / Arginine / bronchial hyperreactivity (BHR) / AIRWAY HYPERRESPONSIVENESS

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